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首页> 外文OA文献 >Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL +/+ autoimmune mice. Correlation of antibody production with delayed onset of lupus-like disease in MRL +/+ mice
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Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL +/+ autoimmune mice. Correlation of antibody production with delayed onset of lupus-like disease in MRL +/+ mice

机译：MRL lpr / lpr和MRL + / +自身免疫小鼠血清中的抗RNA聚合酶I抗体。 MRL + / +小鼠中抗体产生与狼疮样疾病延迟发作的相关性

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Sera from individual MRL/lpr and MRL/++ mice, which develop an autoimmune disease similar to human systemic lupus erythematosus (SLE), were screened over a period of approximately 30 wk for the presence of anti-RNA polymerase I and anti-ssDNA antibodies. Even though onset of the disease is delayed in MRL/++ as compared to MRL/lpr mice, anti- ssDNA antibodies were present in comparable concentrations in the sera of all mice by the age of 6 wk. As observed in sera of human SLE patients, anti-RNA polymerase I antibodies were detected in the sera of all MRL mice. However, unlike the anti-ssDNA antibodies, anti-RNA polymerase I antibodies were detected much later in MRL/++ mice (mean age, 22.8 wk) as compared to MRL/lpr mice (mean age, 9.6 wk). The presence of anti-RNA polymerase I antibodies in sera of MRL mice was thus a much better indicator of disease status than the presence of anti-ssDNA antibodies. The appearance and increase in anti-RNA polymerase I antibodies in the sera of MRL/++ mice correlated (R2 = 0.964) with a precipitous decrease in anti-ssDNA antibodies, starting at about 20 wk of age. These results suggest a possible relationship between the RNA polymerase I and DNA autoimmune reactions.
机译：在大约30 wk的期间内，筛选出现与人类系统性红斑狼疮（SLE）相似的自身免疫性疾病的MRL / lpr和MRL / ++小鼠的血清中是否存在抗RNA聚合酶I和抗ssDNA抗体。即使与MRL / lpr小鼠相比，MRL / ++的疾病发作有所延迟，但到6周龄时，抗ssDNA抗体在所有小鼠血清中的浓度均相当。如在人类SLE患者的血清中观察到的，在所有MRL小鼠的血清中均检测到了抗RNA聚合酶I抗体。然而，与抗ssDNA抗体不同，与MRL / lpr小鼠（平均年龄9.6 wk）相比，在MRL / ++小鼠（平均年龄22.8 wk）中检测到抗RNA聚合酶I抗体的时间要晚得多。因此，MRL小鼠血清中抗RNA聚合酶I抗体的存在比抗ssDNA抗体的存在更好地指示了疾病状态。从约20周龄开始，MRL / ++小鼠血清中抗RNA聚合酶I抗体的出现和增加与抗SsDNA抗体的急剧下降相关（R2 = 0.964）。这些结果表明RNA聚合酶I和DNA自身免疫反应之间可能存在联系。

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